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TitleStructural insights into secretory immunoglobulin A and its interaction with a pneumococcal adhesin.
Journal, issue, pagesCell Res, Vol. 30, Issue 7, Page 602-609, Year 2020
Publish dateMay 12, 2020
AuthorsYuxin Wang / Guopeng Wang / Yaxin Li / Qinyu Zhu / Hao Shen / Ning Gao / Junyu Xiao /
PubMed AbstractSecretory Immunoglobulin A (SIgA) is the most abundant antibody at the mucosal surface. It possesses two additional subunits besides IgA: the joining chain (J-chain) and secretory component (SC). SC ...Secretory Immunoglobulin A (SIgA) is the most abundant antibody at the mucosal surface. It possesses two additional subunits besides IgA: the joining chain (J-chain) and secretory component (SC). SC is the ectodomain of the polymeric immunoglobulin receptor (pIgR), which functions to transport IgA to the mucosa. How the J-chain and pIgR/SC facilitate the assembly and secretion of SIgA remains incompletely understood. Furthermore, during the infection of Streptococcus pneumoniae, the pneumococcal adhesin SpsA hijacks pIgR/SC and SIgA to gain entry to human cells and evade host defense. How SpsA targets pIgR/SC and SIgA also remains elusive. Here we report a cryo-electron microscopy structure of the Fc region of IgA1 (Fcα) in complex with the J-chain and SC (Fcα-J-SC), which reveals the organization principle of SIgA. We also present a structure of Fcα-J-SC complexed with SpsA, which uncovers the specific interactions between SpsA and human pIgR/SC. These results advance the molecular understanding of SIgA and shed light on S. pneumoniae pathogenesis.
External linksCell Res / PubMed:32398862 / PubMed Central
MethodsEM (single particle)
Resolution3.15 - 3.27 Å
Structure data

30004

6lx3

EMDB-30004, PDB-6lx3:
Cryo-EM structure of human secretory immunoglobulin A
Method: EM (single particle) / Resolution: 3.15 Å

30008

6lxw

EMDB-30008, PDB-6lxw:
Cryo-EM structure of human secretory immunoglobulin A in complex with the N-terminal domain of SpsA
Method: EM (single particle) / Resolution: 3.27 Å

Source
  • homo sapiens (human)
  • streptococcus pneumoniae (bacteria)
KeywordsIMMUNE SYSTEM / immunoglobulin / dimer / transcytosis / secreted

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