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TitleSpecificity of bispecific T cell receptors and antibodies targeting peptide-HLA.
Journal, issue, pagesJ. Clin. Invest., Vol. 130, Page 2673-2688, Year 2020
Publish dateMar 18, 2019 (structure data deposition date)
AuthorsHolland, C.J. / Crean, R.M. / Pentier, J.M. / de Wet, B. / Lloyd, A. / Srikannathasan, V. / Lissin, N. / Lloyd, K.A. / Blicher, T.H. / Conroy, P.J. ...Holland, C.J. / Crean, R.M. / Pentier, J.M. / de Wet, B. / Lloyd, A. / Srikannathasan, V. / Lissin, N. / Lloyd, K.A. / Blicher, T.H. / Conroy, P.J. / Hock, M. / Pengelly, R.J. / Spinner, T.E. / Cameron, B. / Potter, E.A. / Jeyanthan, A. / Molloy, P.E. / Sami, M. / Aleksic, M. / Liddy, N. / Robinson, R.A. / Harper, S. / Lepore, M. / Pudney, C.R. / van der Kamp, M.W. / Rizkallah, P.J. / Jakobsen, B.K. / Vuidepot, A. / Cole, D.K.
External linksJ. Clin. Invest. / PubMed:32310221
MethodsX-ray diffraction
Resolution2.3 - 2.95 Å
Structure data

PDB-6r2l:
NYBR1-A2-SLSKILDTV
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-6rsy:
The complex between TCR a7b2 and human Class I MHC HLA-A0201-WT1 with the bound RMFPNAPYL peptide.
Method: X-RAY DIFFRACTION / Resolution: 2.95 Å

Chemicals

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-GOL:
GLYCEROL

ChemComp-SO4:
SULFATE ION

ChemComp-EPE:
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / pH buffer*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / NYBR1 / TCR / HLA-A*0201 / A2 / HLA-A2 / MHC-I / cancer / NY-BR-1 / breast cancer / high affinity TCR / immunotherapy / T-cell / 3D Structure / MHC CLASS I ANTIGEN- TCR - peptide complex

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