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Structure paper

TitleA TfR-Binding Cystine-Dense Peptide Promotes Blood-Brain Barrier Penetration of Bioactive Molecules.
Journal, issue, pagesJ. Mol. Biol., Vol. 432, Page 3989-4009, Year 2020
Publish dateApr 12, 2019 (structure data deposition date)
AuthorsCrook, Z.R. / Girard, E. / Sevilla, G.P. / Merrill, M. / Friend, D. / Rupert, P.B. / Pakiam, F. / Nguyen, E. / Yin, C. / Ruff, R.O. ...Crook, Z.R. / Girard, E. / Sevilla, G.P. / Merrill, M. / Friend, D. / Rupert, P.B. / Pakiam, F. / Nguyen, E. / Yin, C. / Ruff, R.O. / Hopping, G. / Strand, A.D. / Finton, K.A.K. / Coxon, M. / Mhyre, A.J. / Strong, R.K. / Olson, J.M.
External linksJ. Mol. Biol. / PubMed:32304700
MethodsX-ray diffraction
Resolution1.85 - 2.55 Å
Structure data

PDB-6okd:
Crystal Structure of human transferrin receptor in complex with a cystine-dense peptide
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

PDB-6oke:
Crystal structure of an apo Transferrin-Receptor-Binding cystine-dense peptide
Method: X-RAY DIFFRACTION / Resolution: 2.55 Å

Chemicals

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

ChemComp-GOL:
GLYCEROL

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • monosiga brevicollis (eukaryote)
KeywordsTRANSPORT PROTEIN/SIGNALING PROTEIN / protein-protein complex / cystine-dense peptide / TRANSPORT PROTEIN-SIGNALING PROTEIN complex / SIGNALING PROTEIN / alpha-helical hairpin / cystine-dense

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