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Title | Discovery of (2R)-N-[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1H-indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kinase 1 Inhibitor. |
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Journal, issue, pages | J. Med. Chem., Vol. 63, Page 4517-4527, Year 2020 |
Publish date | Aug 21, 2019 (structure data deposition date) |
![]() | Su, Q. / Banks, E. / Bebernitz, G. / Bell, K. / Borenstein, C.F. / Chen, H. / Chuaqui, C.E. / Deng, N. / Ferguson, A.D. / Kawatkar, S. ...Su, Q. / Banks, E. / Bebernitz, G. / Bell, K. / Borenstein, C.F. / Chen, H. / Chuaqui, C.E. / Deng, N. / Ferguson, A.D. / Kawatkar, S. / Grimster, N.P. / Ruston, L. / Lyne, P.D. / Read, J.A. / Peng, X. / Pei, X. / Fawell, S. / Tang, Z. / Throner, S. / Vasbinder, M.M. / Wang, H. / Winter-Holt, J. / Woessner, R. / Wu, A. / Yang, W. / Zinda, M. / Kettle, J.G. |
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Methods | X-ray diffraction |
Resolution | 1.85 - 2.04 Å |
Structure data | ![]() PDB-6sm8: ![]() PDB-6smb: |
Chemicals | ![]() ChemComp-LKT: ![]() ChemComp-EDO: ![]() ChemComp-HOH: ![]() ChemComp-LKQ: |
Source |
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![]() | TRANSFERASE / Janus Kinase 1 kinase domain (JAK1) |