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TitleDevelopment of a 3Mut-Apex-Stabilized Envelope Trimer That Expands HIV-1 Neutralization Breadth When Used To Boost Fusion Peptide-Directed Vaccine-Elicited Responses.
Journal, issue, pagesJ. Virol., Vol. 94, Year 2020
Publish dateFeb 28, 2020 (structure data deposition date)
AuthorsChuang, G.Y. / Lai, Y.T. / Boyington, J.C. / Cheng, C. / Geng, H. / Narpala, S. / Rawi, R. / Schmidt, S.D. / Tsybovsky, Y. / Verardi, R. ...Chuang, G.Y. / Lai, Y.T. / Boyington, J.C. / Cheng, C. / Geng, H. / Narpala, S. / Rawi, R. / Schmidt, S.D. / Tsybovsky, Y. / Verardi, R. / Xu, K. / Yang, Y. / Zhang, B. / Chambers, M. / Changela, A. / Corrigan, A.R. / Kong, R. / Olia, A.S. / Ou, L. / Sarfo, E.K. / Wang, S. / Wu, W. / Doria-Rose, N.A. / McDermott, A.B. / Mascola, J.R. / Kwong, P.D.
External linksJ. Virol. / PubMed:32295908
MethodsX-ray diffraction
Resolution2.4 - 2.716 Å
Structure data

PDB-6vzi:
Crystal Structure of HIV-1 CAP256 RnS-3mut-2G-SOSIP.664 Prefusion Env Trimer in Complex with Human Antibodies 3H109L and 35O22 at 3.5 Angstrom
Method: X-RAY DIFFRACTION / Resolution: 2.716 Å

PDB-6w03:
Crystal Structure of HIV-1 BG505 DS-SOSIP.3mut Prefusion Env Trimer in Complex with Human Antibodies 3H109L and 35O22 at 3.3 Angstrom
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • human immunodeficiency virus 1
  • homo sapiens (human)
KeywordsVIRAL PROTEIN/IMMUNE SYSTEM / HIV-1 Envelope Prefusion Trimer / Entry Inhibitors / VIRAL PROTEIN / VIRAL PROTEIN-IMMUNE SYSTEM complex

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