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Structure paper

TitleHalf Way to Hypusine-Structural Basis for Substrate Recognition by Human Deoxyhypusine Synthase.
Journal, issue, pagesBiomolecules, Vol. 10, Year 2020
Publish dateJan 27, 2020 (structure data deposition date)
AuthorsWator, E. / Wilk, P. / Grudnik, P.
External linksBiomolecules / PubMed:32235505
MethodsX-ray diffraction
Resolution1.41 - 1.69 Å
Structure data

PDB-6xxh:
Crystal Structure of Human Deoxyhypusine Synthase in apo form
Method: X-RAY DIFFRACTION / Resolution: 1.52 Å

PDB-6xxi:
Crystal Structure of Human Deoxyhypusine Synthase in complex with NAD
Method: X-RAY DIFFRACTION / Resolution: 1.679 Å

PDB-6xxj:
Crystal Structure of Human Deoxyhypusine Synthase in complex with spermidine and NAD
Method: X-RAY DIFFRACTION / Resolution: 1.41 Å

PDB-6xxk:
Crystal Structure of Human Deoxyhypusine Synthase in complex with spermidine
Method: X-RAY DIFFRACTION / Resolution: 1.65 Å

PDB-6xxl:
Crystal Structure of Human Deoxyhypusine Synthase in complex with spermine
Method: X-RAY DIFFRACTION / Resolution: 1.69 Å

PDB-6xxm:
Crystal Structure of Human Deoxyhypusine Synthase in complex with putrescine
Method: X-RAY DIFFRACTION / Resolution: 1.67 Å

Chemicals

ChemComp-BME:
BETA-MERCAPTOETHANOL

ChemComp-MRD:
(4R)-2-METHYLPENTANE-2,4-DIOL / precipitant*YM

ChemComp-ACT:
ACETATE ION

ChemComp-OXM:
OXAMIC ACID

ChemComp-HOH:
WATER

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-NAD:
NICOTINAMIDE-ADENINE-DINUCLEOTIDE / NAD*YM

ChemComp-FMT:
FORMIC ACID

ChemComp-SPD:
SPERMIDINE

ChemComp-PGE:
TRIETHYLENE GLYCOL

ChemComp-SPM:
SPERMINE

ChemComp-MPD:
(4S)-2-METHYL-2,4-PENTANEDIOL / precipitant*YM

ChemComp-PUT:
1,4-DIAMINOBUTANE

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / hypusination / deoxyhypusine synthase / EIF5A / translation / hypusine / posttranslational modification / polyamines / deoxyhypusine / spermine

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