タイトル | Isoform-selective regulation of mammalian cryptochromes. |
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ジャーナル・号・ページ | Nat. Chem. Biol., Vol. 16, Page 676-685, Year 2020 |
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掲載日 | 2019年9月10日 (構造データの登録日) |
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著者 | Miller, S. / Son, Y.L. / Aikawa, Y. / Makino, E. / Nagai, Y. / Srivastava, A. / Oshima, T. / Sugiyama, A. / Hara, A. / Abe, K. ...Miller, S. / Son, Y.L. / Aikawa, Y. / Makino, E. / Nagai, Y. / Srivastava, A. / Oshima, T. / Sugiyama, A. / Hara, A. / Abe, K. / Hirata, K. / Oishi, S. / Hagihara, S. / Sato, A. / Tama, F. / Itami, K. / Kay, S.A. / Hatori, M. / Hirota, T. |
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リンク | Nat. Chem. Biol. / PubMed:32231341 |
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手法 | X線回折 |
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解像度 | 2 - 2.25 Å |
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構造データ | PDB-6kx4: Crystal structure of mouse Cryptochrome 1 apo form 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-6kx5: Crystal structure of mouse Cryptochrome 1 in complex with KL044 compound 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-6kx6: Crystal structure of mouse Cryptochrome 1 in complex with KL101 compound 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-6kx7: Crystal structure of mouse Cryptochrome 1 in complex with TH301 compound 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-6kx8: Crystal structure of mouse Cryptochrome 2 in complex with TH301 compound 手法: X-RAY DIFFRACTION / 解像度: 2.25 Å |
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化合物 | ChemComp-DYR: 2-carbazol-9-yl-N-(2-chloranyl-6-cyano-phenyl)ethanamide
ChemComp-DYU: ~{N}-[2-(2,4-dimethylphenyl)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-3,4-dimethyl-benzamide
ChemComp-DYX: 1-(4-chlorophenyl)-N-[2-(4-methoxyphenyl)-5,5-bis(oxidanylidene)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]cyclopentane-1-carboxamide
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由来 |  mus musculus (ハツカネズミ)
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キーワード | CIRCADIAN CLOCK PROTEIN / Cryptochrome / CRY / CRY1 |
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