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-Structure paper
タイトル | Cryo-EM reconstruction of a VPS13 fragment reveals a long groove to channel lipids between membranes. |
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ジャーナル・号・ページ | J Cell Biol, Vol. 219, Issue 5, Year 2020 |
掲載日 | 2020年5月4日 |
![]() | PeiQi Li / Joshua Aaron Lees / C Patrick Lusk / Karin M Reinisch / ![]() |
PubMed 要旨 | A single particle cryo-EM reconstruction of an ∼160-kD N-terminal fragment of the lipid transport protein VPS13 reveals an ∼160-Å long channel lined with hydrophobic residues suitable for ...A single particle cryo-EM reconstruction of an ∼160-kD N-terminal fragment of the lipid transport protein VPS13 reveals an ∼160-Å long channel lined with hydrophobic residues suitable for solubilizing multiple lipid fatty acid moieties. The structure suggests that VPS13 and related proteins, like the autophagy protein ATG2, can act as bridges between organelle membranes to allow bulk lipid flow between organelles. |
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手法 | EM (単粒子) |
解像度 | 3.75 Å |
構造データ | ![]() EMDB-21113: |
由来 |
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