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TitleStructure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein.
Journal, issue, pagesCell, Vol. 181, Issue 2, Page 281-292.e6, Year 2020
Publish dateApr 16, 2020
AuthorsAlexandra C Walls / Young-Jun Park / M Alejandra Tortorici / Abigail Wall / Andrew T McGuire / David Veesler /
PubMed AbstractThe emergence of SARS-CoV-2 has resulted in >90,000 infections and >3,000 deaths. Coronavirus spike (S) glycoproteins promote entry into cells and are the main target of antibodies. We show that SARS- ...The emergence of SARS-CoV-2 has resulted in >90,000 infections and >3,000 deaths. Coronavirus spike (S) glycoproteins promote entry into cells and are the main target of antibodies. We show that SARS-CoV-2 S uses ACE2 to enter cells and that the receptor-binding domains of SARS-CoV-2 S and SARS-CoV S bind with similar affinities to human ACE2, correlating with the efficient spread of SARS-CoV-2 among humans. We found that the SARS-CoV-2 S glycoprotein harbors a furin cleavage site at the boundary between the S/S subunits, which is processed during biogenesis and sets this virus apart from SARS-CoV and SARS-related CoVs. We determined cryo-EM structures of the SARS-CoV-2 S ectodomain trimer, providing a blueprint for the design of vaccines and inhibitors of viral entry. Finally, we demonstrate that SARS-CoV S murine polyclonal antibodies potently inhibited SARS-CoV-2 S mediated entry into cells, indicating that cross-neutralizing antibodies targeting conserved S epitopes can be elicited upon vaccination.
External linksCell / PubMed:32155444 / PubMed Central
MethodsEM (single particle)
Resolution2.8 - 3.2 Å
Structure data

EMDB-21452, PDB-6vxx:
Structure of the SARS-CoV-2 spike glycoprotein (closed state)
Method: EM (single particle) / Resolution: 2.8 Å

EMDB-21457, PDB-6vyb:
SARS-CoV-2 spike ectodomain structure (open state)
Method: EM (single particle) / Resolution: 3.2 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose / N-Acetylglucosamine

Source
  • severe acute respiratory syndrome coronavirus 2
KeywordsVIRAL PROTEIN / Coronavirus / SARS-CoV-2 / SARS-CoV / spike glycoprotein / fusion protein / Structural Genomics / Seattle Structural Genomics Center for Infectious Disease / SSGCID

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