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Structure paper

TitleTCRs with Distinct Specificity Profiles Use Different Binding Modes to Engage an Identical Peptide-HLA Complex.
Journal, issue, pagesJ Immunol., Vol. 204, Page 1943-1953, Year 2020
Publish dateMay 14, 2019 (structure data deposition date)
AuthorsColes, C.H. / Mulvaney, R.M. / Malla, S. / Walker, A. / Smith, K.J. / Lloyd, A. / Lowe, K.L. / McCully, M.L. / Martinez Hague, R. / Aleksic, M. ...Coles, C.H. / Mulvaney, R.M. / Malla, S. / Walker, A. / Smith, K.J. / Lloyd, A. / Lowe, K.L. / McCully, M.L. / Martinez Hague, R. / Aleksic, M. / Harper, J. / Paston, S.J. / Donnellan, Z. / Chester, F. / Wiederhold, K. / Robinson, R.A. / Knox, A. / Stacey, A.R. / Dukes, J. / Baston, E. / Griffin, S. / Jakobsen, B.K. / Vuidepot, A. / Harper, S.
External linksJ Immunol. / PubMed:32102902
MethodsX-ray diffraction
Resolution2.5 - 3.12 Å
Structure data

PDB-6rp9:
Crystal structure of the T-cell receptor NYE_S3 bound to HLA A2*01-SLLMWITQV
Method: X-RAY DIFFRACTION / Resolution: 3.12 Å

PDB-6rpa:
Crystal structure of the T-cell receptor NYE_S2 bound to HLA A2*01-SLLMWITQV
Method: X-RAY DIFFRACTION / Resolution: 2.56 Å

PDB-6rpb:
Crystal structure of the T-cell receptor NYE_S1 bound to HLA A2*01-SLLMWITQV
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / T-cell receptor / peptide-Human leukocyte antigen complex / NY-ESO-1 / cancer testis antigen

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