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-Structure paper
タイトル | Structural Basis for a Convergent Immune Response against Ebola Virus. |
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ジャーナル・号・ページ | Cell Host Microbe, Vol. 27, Issue 3, Page 418-427.e4, Year 2020 |
掲載日 | 2020年3月11日 |
![]() | Hadas Cohen-Dvashi / Matthias Zehner / Stefanie Ehrhardt / Michael Katz / Nadav Elad / Florian Klein / Ron Diskin / ![]() ![]() |
PubMed 要旨 | Ebola virus disease is a severe health problem in Africa. Vaccines that display the Zaire ebolavirus glycoprotein spike complex are a prime component for the effort to combat it. The V3-15/V1-40- ...Ebola virus disease is a severe health problem in Africa. Vaccines that display the Zaire ebolavirus glycoprotein spike complex are a prime component for the effort to combat it. The V3-15/V1-40-based class of antibodies was recently discovered to be a common response in individuals who received the Ebola virus vaccines. These antibodies display attractive properties, and thus likely contribute to the efficacy of the vaccines. Here, we use cryo-EM to elucidate how three V3-15/V1-40 antibodies from different individuals target the virus and found a convergent mechanism against a partially conserved site on the spike complex. Our study rationalizes the selection of the V3-15/V1-40 germline genes for specifically targeting this site and highlights Ebolavirus species-specific sequence divergences that may restrict breadth of V3-15/V1-40-based humoral response. The results from this study could help develop improved immunization schemes and further enable the design of immunogens that would be efficacious against a broader set of Ebolavirus species. |
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手法 | EM (単粒子) |
解像度 | 2.91 - 3.49 Å |
構造データ | EMDB-10118, PDB-6s8d: EMDB-10123, PDB-6s8i: EMDB-10124, PDB-6s8j: |
化合物 | ![]() ChemComp-HOH: |
由来 |
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![]() | VIRAL PROTEIN / Ebola / glycoprotein / antibodies |