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TitleStructural Basis for a Convergent Immune Response against Ebola Virus.
Journal, issue, pagesCell Host Microbe, Vol. 27, Issue 3, Page 418-427.e4, Year 2020
Publish dateMar 11, 2020
AuthorsHadas Cohen-Dvashi / Matthias Zehner / Stefanie Ehrhardt / Michael Katz / Nadav Elad / Florian Klein / Ron Diskin /
PubMed AbstractEbola virus disease is a severe health problem in Africa. Vaccines that display the Zaire ebolavirus glycoprotein spike complex are a prime component for the effort to combat it. The V3-15/V1-40- ...Ebola virus disease is a severe health problem in Africa. Vaccines that display the Zaire ebolavirus glycoprotein spike complex are a prime component for the effort to combat it. The V3-15/V1-40-based class of antibodies was recently discovered to be a common response in individuals who received the Ebola virus vaccines. These antibodies display attractive properties, and thus likely contribute to the efficacy of the vaccines. Here, we use cryo-EM to elucidate how three V3-15/V1-40 antibodies from different individuals target the virus and found a convergent mechanism against a partially conserved site on the spike complex. Our study rationalizes the selection of the V3-15/V1-40 germline genes for specifically targeting this site and highlights Ebolavirus species-specific sequence divergences that may restrict breadth of V3-15/V1-40-based humoral response. The results from this study could help develop improved immunization schemes and further enable the design of immunogens that would be efficacious against a broader set of Ebolavirus species.
External linksCell Host Microbe / PubMed:32059794
MethodsEM (single particle)
Resolution2.91 - 3.49 Å
Structure data

10118

6s8d

EMDB-10118, PDB-6s8d:
Structure of ZEBOV GP in complex with 1T0227 antibody
Method: EM (single particle) / Resolution: 3.49 Å

10123

6s8i

EMDB-10123, PDB-6s8i:
Structure of ZEBOV GP in complex with 3T0265 antibody
Method: EM (single particle) / Resolution: 2.99 Å

10124

6s8j

EMDB-10124, PDB-6s8j:
Structure of ZEBOV GP in complex with 5T0180 antibody
Method: EM (single particle) / Resolution: 2.91 Å

Chemicals

ChemComp-HOH:
WATER / Water

Source
  • ebola virus
  • homo sapiens (human)
KeywordsVIRAL PROTEIN / Ebola / glycoprotein / antibodies

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