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TitleSelective and Potent CDK8/19 Inhibitors Enhance NK-Cell Activity and Promote Tumor Surveillance.
Journal, issue, pagesMol. Cancer Ther., Vol. 19, Page 1018-1030, Year 2020
Publish dateFeb 25, 2019 (structure data deposition date)
AuthorsHofmann, M.H. / Mani, R. / Engelhardt, H. / Impagnatiello, M.A. / Carotta, S. / Kerenyi, M. / Lorenzo-Herrero, S. / Bottcher, J. / Scharn, D. / Arnhof, H. ...Hofmann, M.H. / Mani, R. / Engelhardt, H. / Impagnatiello, M.A. / Carotta, S. / Kerenyi, M. / Lorenzo-Herrero, S. / Bottcher, J. / Scharn, D. / Arnhof, H. / Zoephel, A. / Schnitzer, R. / Gerstberger, T. / Sanderson, M.P. / Rajgolikar, G. / Goswami, S. / Vasu, S. / Ettmayer, P. / Gonzalez, S. / Pearson, M. / McConnell, D.B. / Kraut, N. / Muthusamy, N. / Moll, J.
External linksMol. Cancer Ther. / PubMed:32024684
MethodsX-ray diffraction
Resolution2.19 - 2.7 Å
Structure data

PDB-6qtg:
Crystal structure of human CDK8/CYCC in complex with BI-1347
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-6qtj:
Crystal structure of human CDK8/CYCC in complex with BI 919811
Method: X-RAY DIFFRACTION / Resolution: 2.48 Å

PDB-6r3s:
CRYSTAL STRUCTURE OF CDK8-CycC IN COMPLEX WITH COMPOUND 1
Method: X-RAY DIFFRACTION / Resolution: 2.19 Å

Chemicals

ChemComp-JH8:
2-[4-(4-isoquinolin-4-ylphenyl)pyrazol-1-yl]-~{N},~{N}-dimethyl-ethanamide

ChemComp-HOH:
WATER

ChemComp-JHK:
~{N},~{N}-dimethyl-2-[4-[4-(2,6-naphthyridin-4-yl)phenyl]pyrazol-1-yl]ethanamide

ChemComp-JRE:
6-[5-chloranyl-4-[(1~{S})-1-oxidanylethyl]pyridin-3-yl]-3,4-dihydro-2~{H}-1,8-naphthyridine-1-carboxamide

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-FMT:
FORMIC ACID

Source
  • homo sapiens (human)
KeywordsCELL CYCLE / Inhibitor / Complex / KINASE

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