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Structure paper

TitleDNA aptamers against the DUX4 protein reveal novel therapeutic implications for FSHD.
Journal, issue, pagesFaseb J., Vol. 34, Page 4573-4590, Year 2020
Publish dateSep 4, 2019 (structure data deposition date)
AuthorsKlingler, C. / Ashley, J. / Shi, K. / Stiefvater, A. / Kyba, M. / Sinnreich, M. / Aihara, H. / Kinter, J.
External linksFaseb J. / PubMed:32020675
MethodsX-ray diffraction
Resolution2.34 - 3.21 Å
Structure data

PDB-6u81:
Crystal Structure of the Double Homeodomain of DUX4 in Complex with a DNA aptamer
Method: X-RAY DIFFRACTION / Resolution: 2.34 Å

PDB-6u82:
Crystal Structure of the Double Homeodomain of DUX4 in Complex with a DNA aptamer containing bulge and loop
Method: X-RAY DIFFRACTION / Resolution: 3.21 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsDNA BINDING PROTEIN/DNA / DUX tandem homeodomains / DNA BINDING PROTEIN-DNA complex

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