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TitleInsight to the residue in P2 position prevents the peptide inhibitor from being hydrolyzed by serine proteases.
Journal, issue, pagesBiosci. Biotechnol. Biochem., Vol. 84, Page 1153-1159, Year 2020
Publish dateJan 21, 2020 (structure data deposition date)
AuthorsXue, G. / Xie, X. / Zhou, Y. / Yuan, C. / Huang, M. / Jiang, L.
External linksBiosci. Biotechnol. Biochem. / PubMed:32019421
MethodsX-ray diffraction
Resolution1.4 Å
Structure data

PDB-6xvd:
Crystal structure of complex of urokinase and a upain-1 variant(W3F) in pH7.4 condition
Method: X-RAY DIFFRACTION / Resolution: 1.4 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsPEPTIDE BINDING PROTEIN / upain-1-W3F / urokinase / Cyclic peptide inhibitor

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