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TitleEfficient synthesis of tert-butyl 3-cyano-3-cyclopropyl-2-oxopyrrolidine-4-carboxylates: Highly functionalized 2-pyrrolidinone enabling access to novel macrocyclic Tyk2 inhibitors.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 30, Page 126963-126963, Year 2020
Publish dateMay 7, 2019 (structure data deposition date)
AuthorsSasaki, Y. / Tokuhara, H. / Ohba, Y. / Okabe, A. / Nakayama, M. / Nakagawa, H. / Skene, R. / Hoffman, I. / Zou, H. / Yoshida, M.
External linksBioorg. Med. Chem. Lett. / PubMed:31980341
MethodsX-ray diffraction
Resolution2.5 Å
Structure data

PDB-6ova:
Crystal Structure of TYK2 with novel pyrrolidinone inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-N9G:
6-({4-[(3S)-3-cyano-3-cyclopropyl-2-oxopyrrolidin-1-yl]pyridin-2-yl}amino)-N,N-dimethylpyridine-3-carboxamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / Inhibitor / Complex / TRANSFERASE-TRANSFERASE INHIBITOR complex

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