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TitleMolecular mechanism of two nanobodies that inhibit PAI-1 activity reveals a modulation at distinct stages of the PAI-1/plasminogen activator interaction.
Journal, issue, pagesJ. Thromb. Haemost., Vol. 18, Page 681-692, Year 2020
Publish dateJun 25, 2018 (structure data deposition date)
AuthorsSillen, M. / Weeks, S.D. / Zhou, X. / Komissarov, A.A. / Florova, G. / Idell, S. / Strelkov, S.V. / Declerck, P.J.
External linksJ. Thromb. Haemost. / PubMed:31858714
MethodsX-ray diffraction
Resolution2.03 - 2.32 Å
Structure data

PDB-6gwn:
Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-W175F) in Complex with Two Inhibitory Nanobodies (VHH-2g-42, VHH-2w-64)
Method: X-RAY DIFFRACTION / Resolution: 2.03 Å

PDB-6gwp:
Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-stab) in Complex with Two Inhibitory Nanobodies (VHH-2g-42, VHH-2w-64)
Method: X-RAY DIFFRACTION / Resolution: 2.28 Å

PDB-6gwq:
Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-stab) in Complex with an Inhibitory Nanobody (VHH-2g-42)
Method: X-RAY DIFFRACTION / Resolution: 2.32 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • vicugna pacos (alpaca)
KeywordsHYDROLASE / plasminogen activator inhibitor-1 / PAI-1 / PAI-1-W175F / serpin / protease inhibitor / serine protease inhibitor / nanobody / antibody fragment / protein complex / PAI-1-stab

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