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-Structure paper
Title | Molecular mechanism of two nanobodies that inhibit PAI-1 activity reveals a modulation at distinct stages of the PAI-1/plasminogen activator interaction. |
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Journal, issue, pages | J. Thromb. Haemost., Vol. 18, Page 681-692, Year 2020 |
Publish date | Jun 25, 2018 (structure data deposition date) |
![]() | Sillen, M. / Weeks, S.D. / Zhou, X. / Komissarov, A.A. / Florova, G. / Idell, S. / Strelkov, S.V. / Declerck, P.J. |
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Methods | X-ray diffraction |
Resolution | 2.03 - 2.32 Å |
Structure data | ![]() PDB-6gwn: ![]() PDB-6gwp: ![]() PDB-6gwq: |
Chemicals | ![]() ChemComp-HOH: |
Source |
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![]() | HYDROLASE / plasminogen activator inhibitor-1 / PAI-1 / PAI-1-W175F / serpin / protease inhibitor / serine protease inhibitor / nanobody / antibody fragment / protein complex / PAI-1-stab |