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Structure paper

TitleThe terminal sialic acid of stage-specific embryonic antigen-4 has a crucial role in binding to a cancer-targeting antibody.
Journal, issue, pagesJ. Biol. Chem., Vol. 295, Page 1009-1020, Year 2020
Publish dateSep 26, 2019 (structure data deposition date)
AuthorsSoliman, C. / Chua, J.X. / Vankemmelbeke, M. / McIntosh, R.S. / Guy, A.J. / Spendlove, I. / Durrant, L.G. / Ramsland, P.A.
External linksJ. Biol. Chem. / PubMed:31831622
MethodsX-ray diffraction
Resolution1.52 - 2.74 Å
Structure data

PDB-6ug7:
Complex of ch28/11 Fab and SSEA-4 (tetragonal form)
Method: X-RAY DIFFRACTION / Resolution: 1.52 Å

PDB-6ug8:
Complex of ch28/11 Fab and SSEA-4 (monoclinic form)
Method: X-RAY DIFFRACTION / Resolution: 1.89 Å

PDB-6ug9:
Complex of ch28/11 Fab and SSEA-4 (hexagonal form)
Method: X-RAY DIFFRACTION / Resolution: 2.74 Å

PDB-6uga:
ch28/11 Fab (monoclinic form)
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-03S:
methanesulfonic acid

Source
  • mus musculus (house mouse)
KeywordsIMMUNE SYSTEM / IMMUNOGLOBULIN / CHIMERIC ANTIBODY / ANTIGEN BINDING FRAGMENT / SSEA-4 / COMPLEX

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