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TitleStructural Basis for Finding OG Lesions and Avoiding Undamaged G by the DNA Glycosylase MutY.
Journal, issue, pagesAcs Chem. Biol., Vol. 15, Page 93-102, Year 2020
Publish dateAug 1, 2019 (structure data deposition date)
AuthorsRusselburg, L.P. / O'Shea Murray, V.L. / Demir, M. / Knutsen, K.R. / Sehgal, S.L. / Cao, S. / David, S.S. / Horvath, M.P.
External linksAcs Chem. Biol. / PubMed:31829624
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-6q0c:
MutY adenine glycosylase bound to DNA containing a transition state analog (1N) paired with undamaged dG
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-6u7t:
MutY adenine glycosylase bound to DNA containing a transition state analog (1N) paired with d(8-oxo-G)
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-SF4:
IRON/SULFUR CLUSTER

ChemComp-CA:
Unknown entry

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • geobacillus stearothermophilus (bacteria)
  • synthetic construct (others)
Keywordshydrolase/DNA / Protein-DNA complex / DNA repair / transition state analog / hydrolase-DNA complex / HYDROLASE

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