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Structure paper

TitleDistinct Hepatic PKA and CDK Signaling Pathways Control Activity-Independent Pyruvate Kinase Phosphorylation and Hepatic Glucose Production.
Journal, issue, pagesCell Rep, Vol. 29, Page 3394-3404.e9, Year 2019
Publish dateAug 7, 2018 (structure data deposition date)
AuthorsGassaway, B.M. / Cardone, R.L. / Padyana, A.K. / Petersen, M.C. / Judd, E.T. / Hayes, S. / Tong, S. / Barber, K.W. / Apostolidi, M. / Abulizi, A. ...Gassaway, B.M. / Cardone, R.L. / Padyana, A.K. / Petersen, M.C. / Judd, E.T. / Hayes, S. / Tong, S. / Barber, K.W. / Apostolidi, M. / Abulizi, A. / Sheetz, J.B. / Aerni, H.R. / Gross, S. / Kung, C. / Samuel, V.T. / Shulman, G.I. / Kibbey, R.G. / Rinehart, J.
External linksCell Rep / PubMed:31825824
MethodsX-ray diffraction
Resolution2.19 - 2.36 Å
Structure data

PDB-6ech:
Pyruvate Kinase Isoform L-type with phosphorylated Ser12 (pS12) in complex with FBP
Method: X-RAY DIFFRACTION / Resolution: 2.19 Å

PDB-6eck:
Pyruvate Kinase Isoform L-type with phosphorylated Ser113 (pS113) in complex with FBP
Method: X-RAY DIFFRACTION / Resolution: 2.36 Å

Chemicals

ChemComp-FBP:
1,6-di-O-phosphono-beta-D-fructofuranose

ChemComp-MG:
Unknown entry

ChemComp-ATP:
ADENOSINE-5'-TRIPHOSPHATE / ATP, energy-carrying molecule*YM

ChemComp-OXL:
OXALATE ION

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-PG4:
TETRAETHYLENE GLYCOL / precipitant*YM

ChemComp-PGE:
TRIETHYLENE GLYCOL

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-GOL:
GLYCEROL

ChemComp-FLC:
CITRATE ANION

Source
  • rattus norvegicus (Norway rat)
KeywordsTRANSFERASE / PKL / pyruvate kinase / Glycolysis

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