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-Structure paper
Title | Discovery and Optimization of Dibenzodiazepinones as Allosteric Mutant-Selective EGFR Inhibitors. |
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Journal, issue, pages | Acs Med. Chem. Lett., Vol. 10, Page 1549-1553, Year 2019 |
Publish date | May 19, 2019 (structure data deposition date) |
Authors | De Clercq, D.J.H. / Heppner, D.E. / To, C. / Jang, J. / Park, E. / Yun, C.H. / Mushajiang, M. / Shin, B.H. / Gero, T.W. / Scott, D.A. ...De Clercq, D.J.H. / Heppner, D.E. / To, C. / Jang, J. / Park, E. / Yun, C.H. / Mushajiang, M. / Shin, B.H. / Gero, T.W. / Scott, D.A. / Janne, P.A. / Eck, M.J. / Gray, N.S. |
External links | Acs Med. Chem. Lett. / PubMed:31749909 |
Methods | X-ray diffraction |
Resolution | 1.9 - 2.8 Å |
Structure data | PDB-6p1d: PDB-6p1l: PDB-6p8q: |
Chemicals | ChemComp-NQ1: ChemComp-ANP: ChemComp-MG: ChemComp-HOH: ChemComp-9LL: ChemComp-O57: ChemComp-AMP: ChemComp-EDO: |
Source |
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Keywords | Transferase/Transferase Inhibitor / EGFR / Cancer / Inhibitor / SIGNALING PROTEIN / Transferase-Transferase Inhibitor complex / allosteric inhibitor / TRANSFERASE |