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TitleA high-affinity human PD-1/PD-L2 complex informs avenues for small-molecule immune checkpoint drug discovery.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 116, Page 24500-24506, Year 2019
Publish dateOct 10, 2019 (structure data deposition date)
AuthorsTang, S. / Kim, P.S.
External linksProc. Natl. Acad. Sci. USA / PubMed:31727844
MethodsX-ray diffraction
Resolution1.183 - 1.986 Å
Structure data

PDB-6umt:
High-affinity human PD-1 PD-L2 complex
Method: X-RAY DIFFRACTION / Resolution: 1.986 Å

PDB-6umu:
Human apo PD-1 triple mutant
Method: X-RAY DIFFRACTION / Resolution: 1.183 Å

PDB-6umv:
Human apo PD-1 double mutant
Method: X-RAY DIFFRACTION / Resolution: 1.424 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-CL:
Unknown entry

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / PD-1 / PD-L2 / immune checkpoint

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