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Structure paper

TitleMutagenesis facilitated crystallization of GLP-1R.
Journal, issue, pagesIucrj, Vol. 6, Page 996-1006, Year 2019
Publish dateJul 23, 2019 (structure data deposition date)
AuthorsXu, Y. / Wang, Y. / Liu, K. / Peng, Y. / Yao, D. / Tao, H. / Liu, H. / Song, G.
External linksIucrj / PubMed:31709055
MethodsX-ray diffraction
Resolution2.8 - 3.1 Å
Structure data

PDB-6kjv:
Structure of thermal-stabilised(M9) human GLP-1 receptor transmembrane domain
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-6kk1:
Structure of thermal-stabilised(M8) human GLP-1 receptor transmembrane domain
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-6kk7:
Structure of thermal-stabilised(M6) human GLP-1 receptor transmembrane domain
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

Chemicals

ChemComp-97Y:
N-{4-[(R)-(3,3-dimethylcyclobutyl)({6-[4-(trifluoromethyl)-1H-imidazol-1-yl]pyridin-3-yl}amino)methyl]benzene-1-carbonyl}-beta-alanine

ChemComp-OLC:
(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • enterobacteria phage t4 (virus)
KeywordsSIGNALING PROTEIN / GPCR / seven-transmembrane / allosteric modulators / diabetes

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