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TitleCrystal structures of angiotensin-converting enzyme from Anopheles gambiae in its native form and with a bound inhibitor.
Journal, issue, pagesBiochem. J., Vol. 476, Page 3505-3520, Year 2019
Publish dateJun 19, 2019 (structure data deposition date)
AuthorsCashman, J.S. / Cozier, G.E. / Harrison, C. / Isaac, R.E. / Acharya, K.R.
External linksBiochem. J. / PubMed:31682720
MethodsX-ray diffraction
Resolution2.2 - 2.5 Å
Structure data

PDB-6s1y:
Crystal structure of Anopheles gambiae AnoACE2 in complex with gamma-Polyglutamic Acid.
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-6s1z:
Crystal structure of Anopheles gambiae AnoACE2 in complex with fosinoprilat
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-ZN:
Unknown entry

ChemComp-KSN:
(2~{S})-2-[[(4~{S})-4-azanyl-5-oxidanyl-5-oxidanylidene-pentanoyl]amino]pentanedioic acid

ChemComp-HOH:
WATER

ChemComp-KS8:
fosinoprilat / inhibitor*YM

Source
  • anopheles gambiae (African malaria mosquito)
KeywordsHYDROLASE / metalloprotease / mosquito control / insecticide design / fosinoprilat

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