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-Structure paper
Title | Validation of Human Sterol 14 alpha-Demethylase (CYP51) Druggability: Structure-Guided Design, Synthesis, and Evaluation of Stoichiometric, Functionally Irreversible Inhibitors. |
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Journal, issue, pages | J. Med. Chem., Vol. 62, Page 10391-10401, Year 2019 |
Publish date | Aug 8, 2019 (structure data deposition date) |
Authors | Friggeri, L. / Hargrove, T.Y. / Wawrzak, Z. / Guengerich, F.P. / Lepesheva, G.I. |
External links | J. Med. Chem. / PubMed:31663733 |
Methods | X-ray diffraction |
Resolution | 2.8 Å |
Structure data | PDB-6q2t: |
Chemicals | ChemComp-HEM: ChemComp-PJM: ChemComp-DXC: ChemComp-HOH: |
Source |
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Keywords | OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR / monooxygenase / sterol biosynthesis / cytochrome P450 / structure-based drug design / OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex |