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Structure paper

TitleBroadly protective human antibodies that target the active site of influenza virus neuraminidase.
Journal, issue, pagesScience, Vol. 366, Page 499-504, Year 2019
Publish dateAug 6, 2019 (structure data deposition date)
AuthorsStadlbauer, D. / Zhu, X. / McMahon, M. / Turner, J.S. / Wohlbold, T.J. / Schmitz, A.J. / Strohmeier, S. / Yu, W. / Nachbagauer, R. / Mudd, P.A. ...Stadlbauer, D. / Zhu, X. / McMahon, M. / Turner, J.S. / Wohlbold, T.J. / Schmitz, A.J. / Strohmeier, S. / Yu, W. / Nachbagauer, R. / Mudd, P.A. / Wilson, I.A. / Ellebedy, A.H. / Krammer, F.
External linksScience / PubMed:31649200
MethodsX-ray diffraction
Resolution2.45 - 3.446 Å
Structure data

PDB-6q1z:
Crystal structure of human 1G04 Fab in complex with influenza virus neuraminidase from A/Hunan/02650/2016 (H7N9)
Method: X-RAY DIFFRACTION / Resolution: 3.446 Å

PDB-6q20:
Crystal structure of human 1E01 Fab in complex with influenza virus neuraminidase from A/Japan/305/1957 (H2N2)
Method: X-RAY DIFFRACTION / Resolution: 2.45 Å

PDB-6q23:
Crystal structure of human 1G01 Fab in complex with influenza virus neuraminidase from A/California/04/2009 (H1N1)
Method: X-RAY DIFFRACTION / Resolution: 3.27 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-CA:
Unknown entry

ChemComp-HOH:
WATER

Source
  • influenza a virus
  • homo sapiens (human)
  • influenza a virus (strain a/japan/305/1957 h2n2)
  • influenza a virus (a/california/04/2009 (h1n1)
KeywordsVIRAL PROTEIN / HYDROLASE/IMMUNE SYSTEM / broadly protective human antibody / neuraminidase / inhibition / active site / antibody-neuraminidase complex / HYDROLASE-IMMUNE SYSTEM complex

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