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TitleArchitecture of African swine fever virus and implications for viral assembly.
Journal, issue, pagesScience, Vol. 366, Issue 6465, Page 640-644, Year 2019
Publish dateNov 1, 2019
AuthorsNan Wang / Dongming Zhao / Jialing Wang / Yangling Zhang / Ming Wang / Yan Gao / Fang Li / Jingfei Wang / Zhigao Bu / Zihe Rao / Xiangxi Wang /
PubMed AbstractAfrican swine fever virus (ASFV) is a giant and complex DNA virus that causes a highly contagious and often lethal swine disease for which no vaccine is available. Using an optimized image ...African swine fever virus (ASFV) is a giant and complex DNA virus that causes a highly contagious and often lethal swine disease for which no vaccine is available. Using an optimized image reconstruction strategy, we solved the ASFV capsid structure up to 4.1 angstroms, which is built from 17,280 proteins, including one major (p72) and four minor (M1249L, p17, p49, and H240R) capsid proteins organized into pentasymmetrons and trisymmetrons. The atomic structure of the p72 protein informs putative conformational epitopes, distinguishing ASFV from other nucleocytoplasmic large DNA viruses. The minor capsid proteins form a complicated network below the outer capsid shell, stabilizing the capsid by holding adjacent capsomers together. Acting as core organizers, 100-nanometer-long M1249L proteins run along each edge of the trisymmetrons that bridge two neighboring pentasymmetrons and form extensive intermolecular networks with other capsid proteins, driving the formation of the capsid framework. These structural details unveil the basis of capsid stability and assembly, opening up new avenues for African swine fever vaccine development.
External linksScience / PubMed:31624094
MethodsEM (single particle)
Resolution4.1 - 8.8 Å
Structure data

EMDB-0810:
Asymmetric unit of African Swine Fever virus capsid
Method: EM (single particle) / Resolution: 4.8 Å

EMDB-0811:
Edge block of African swine fever virus capsid
Method: EM (single particle) / Resolution: 4.7 Å

EMDB-0812:
Facet block of African Swine Fever virus capsid
Method: EM (single particle) / Resolution: 4.7 Å

EMDB-0813:
Vertex block of African Swine Fever virus capsid
Method: EM (single particle) / Resolution: 5.1 Å

0814

6l2t

EMDB-0814, PDB-6l2t:
African swine fever virus major capsid protein p72
Method: EM (single particle) / Resolution: 4.1 Å

EMDB-0815:
African Swine Fever Virus
Method: EM (single particle) / Resolution: 8.8 Å

Source
  • african swine fever virus
KeywordsVIRAL PROTEIN / African Swine Fever virus capsomer / Trisymmetron / NCLDV

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