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Structure paper

TitleA Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization.
Journal, issue, pagesCell Rep, Vol. 29, Page 62-75.e7, Year 2019
Publish dateSep 14, 2018 (structure data deposition date)
AuthorsWojnarowicz, P.M. / Lima E Silva, R. / Ohnaka, M. / Lee, S.B. / Chin, Y. / Kulukian, A. / Chang, S.H. / Desai, B. / Garcia Escolano, M. / Shah, R. ...Wojnarowicz, P.M. / Lima E Silva, R. / Ohnaka, M. / Lee, S.B. / Chin, Y. / Kulukian, A. / Chang, S.H. / Desai, B. / Garcia Escolano, M. / Shah, R. / Garcia-Cao, M. / Xu, S. / Kadam, R. / Goldgur, Y. / Miller, M.A. / Ouerfelli, O. / Yang, G. / Arakawa, T. / Albanese, S.K. / Garland, W.A. / Stoller, G. / Chaudhary, J. / Norton, L. / Soni, R.K. / Philip, J. / Hendrickson, R.C. / Iavarone, A. / Dannenberg, A.J. / Chodera, J.D. / Pavletich, N. / Lasorella, A. / Campochiaro, P.A. / Benezra, R.
External linksCell Rep / PubMed:31577956
MethodsX-ray diffraction
Resolution1.5 - 1.901 Å
Structure data

PDB-6mgm:
Helix-Loop-helix motif of mouse DNA-binding protein inhibitor ID-1
Method: X-RAY DIFFRACTION / Resolution: 1.791 Å

PDB-6mgn:
mouse Id1 (51-104) - human hE47 (348-399) complex
Method: X-RAY DIFFRACTION / Resolution: 1.901 Å

PDB-6u2u:
Helix-Loop-helix motif of mouse DNA-binding protein inhibitor ID-1
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsDNA BINDING PROTEIN / Helix-loop-helix DNA-binding protein inhibitor / DNA-binding protein inhibitor ID-1 / transcription factor E2-alpha isoform E47 [Homo sapiens] / DNA BINDING PROTEIN INHIBITOR / Helix-loop-helix / DNA-binding protein inhibitor

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