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Structure paper

TitleFunctional, Biophysical, and Structural Characterization of Human IgG1 and IgG4 Fc Variants with Ablated Immune Functionality.
Journal, issue, pagesAntibodies, Vol. 6, Year 2017
Publish dateJun 15, 2017 (structure data deposition date)
AuthorsTam, S.H. / McCarthy, S.G. / Armstrong, A.A. / Somani, S. / Wu, S.J. / Liu, X. / Gervais, A. / Ernst, R. / Saro, D. / Decker, R. ...Tam, S.H. / McCarthy, S.G. / Armstrong, A.A. / Somani, S. / Wu, S.J. / Liu, X. / Gervais, A. / Ernst, R. / Saro, D. / Decker, R. / Luo, J. / Gilliland, G.L. / Chiu, M.L. / Scallon, B.J.
External linksAntibodies / PubMed:31548527
MethodsX-ray diffraction
Resolution1.85 - 1.9 Å
Structure data

PDB-5w5l:
Crystal structure of human IgG1-Sigma Fc fragment
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-5w5m:
Crystal structure of human IgG4-Sigma1 Fc fragment
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-5w5n:
Crystal structure of human IgG4-Sigma2 Fc fragment
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-GOL:
GLYCEROL

ChemComp-ACT:
ACETATE ION

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / FC / IMMUNOGLOBULIN FOLD

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