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Structure paper

TitleA single T cell epitope drives the neutralizing anti-drug antibody response to natalizumab in multiple sclerosis patients.
Journal, issue, pagesNat. Med., Vol. 25, Page 1402-1407, Year 2019
Publish dateJan 9, 2018 (structure data deposition date)
AuthorsCassotta, A. / Mikol, V. / Bertrand, T. / Pouzieux, S. / Le Parc, J. / Ferrari, P. / Dumas, J. / Auer, M. / Deisenhammer, F. / Gastaldi, M. ...Cassotta, A. / Mikol, V. / Bertrand, T. / Pouzieux, S. / Le Parc, J. / Ferrari, P. / Dumas, J. / Auer, M. / Deisenhammer, F. / Gastaldi, M. / Franciotta, D. / Silacci-Fregni, C. / Fernandez Rodriguez, B. / Giacchetto-Sasselli, I. / Foglierini, M. / Jarrossay, D. / Geiger, R. / Sallusto, F. / Lanzavecchia, A. / Piccoli, L.
External linksNat. Med. / PubMed:31501610
MethodsX-ray diffraction
Resolution2.03 - 2.788 Å
Structure data

PDB-6fg1:
CRYSTAL STRUCTURE OF FAB OF NATALIZUMAB IN COMPLEX WITH FAB OF NAA32.
Method: X-RAY DIFFRACTION / Resolution: 2.03 Å

PDB-6fg2:
CRYSTAL STRUCTURE OF FAB OF NATALIZUMAB IN COMPLEX WITH FAB OF NAA84.
Method: X-RAY DIFFRACTION / Resolution: 2.788 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / ANTIBODY

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