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-Structure paper
Title | Evaluation of a Series of beta-Secretase 1 Inhibitors Containing Novel Heteroaryl-Fused-Piperazine Amidine Warheads. |
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Journal, issue, pages | Acs Med. Chem. Lett., Vol. 10, Page 1159-1165, Year 2019 |
Publish date | Mar 26, 2019 (structure data deposition date) |
![]() | Oehlrich, D. / Peschiulli, A. / Tresadern, G. / Van Gool, M. / Vega, J.A. / De Lucas, A.I. / Alonso de Diego, S.A. / Prokopcova, H. / Austin, N. / Van Brandt, S. ...Oehlrich, D. / Peschiulli, A. / Tresadern, G. / Van Gool, M. / Vega, J.A. / De Lucas, A.I. / Alonso de Diego, S.A. / Prokopcova, H. / Austin, N. / Van Brandt, S. / Surkyn, M. / De Cleyn, M. / Vos, A. / Rombouts, F.J.R. / Macdonald, G. / Moechars, D. / Gijsen, H.J.M. / Trabanco, A.A. |
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Methods | X-ray diffraction |
Resolution | 2 Å |
Structure data | ![]() PDB-6od6: |
Chemicals | ![]() ChemComp-M7D: ![]() ChemComp-GOL: ![]() ChemComp-HOH: |
Source |
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![]() | HYDROLASE/INHIBITOR / Bace Protease / hydrolase / HYDROLASE-INHIBITOR complex |