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TitleConvergent Structures Illuminate Features for Germline Antibody Binding and Pan-Lassa Virus Neutralization.
Journal, issue, pagesCell, Vol. 178, Page 1004-1015.e14, Year 2019
Publish dateJun 9, 2019 (structure data deposition date)
AuthorsHastie, K.M. / Cross, R.W. / Harkins, S.S. / Zandonatti, M.A. / Koval, A.P. / Heinrich, M.L. / Rowland, M.M. / Robinson, J.E. / Geisbert, T.W. / Garry, R.F. ...Hastie, K.M. / Cross, R.W. / Harkins, S.S. / Zandonatti, M.A. / Koval, A.P. / Heinrich, M.L. / Rowland, M.M. / Robinson, J.E. / Geisbert, T.W. / Garry, R.F. / Branco, L.M. / Saphire, E.O.
External linksCell / PubMed:31398326
MethodsX-ray diffraction
Resolution3.5 - 4 Å
Structure data

PDB-6p91:
Structure of Lassa virus glycoprotein bound to Fab 18.5C
Method: X-RAY DIFFRACTION / Resolution: 4 Å

PDB-6p95:
Structure of Lassa virus glycoprotein in complex with Fab 25.6A
Method: X-RAY DIFFRACTION / Resolution: 3.5 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • lassa mammarenavirus
  • homo sapiens (human)
  • lassa virus
  • lassa virus (strain mouse/sierra leone/josiah/1976)
Keywordsviral protein/immune system / Lassa virus / glycoprotein / antibody / VIRAL PROTEIN / viral protein-immune system complex

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