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Structure paper

TitleStructural Basis for Target-Directed MicroRNA Degradation.
Journal, issue, pagesMol. Cell, Vol. 75, Page 1243-1255.e7, Year 2019
Publish dateSep 5, 2018 (structure data deposition date)
AuthorsSheu-Gruttadauria, J. / Pawlica, P. / Klum, S.M. / Wang, S. / Yario, T.A. / Schirle Oakdale, N.T. / Steitz, J.A. / MacRae, I.J.
External linksMol. Cell / PubMed:31353209
MethodsX-ray diffraction
Resolution2.5 - 3.8 Å
Structure data

PDB-6mdz:
Human Argonaute2-miR-122 bound to a target RNA with two central mismatches (bu2)
Method: X-RAY DIFFRACTION / Resolution: 3.4 Å

PDB-6mfn:
Human Argonaute2-miR-27a bound to HSUR1 target RNA
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-6mfr:
Human Argonaute2-miR-122 bound to a target RNA with three central mismatches (bu3)
Method: X-RAY DIFFRACTION / Resolution: 3.6 Å

PDB-6nit:
Human Argonaute2-miR-122 bound to a target RNA with four central mismatches (bu4)
Method: X-RAY DIFFRACTION / Resolution: 3.8 Å

Chemicals

ChemComp-IPH:
PHENOL

ChemComp-HOH:
WATER

ChemComp-PO4:
PHOSPHATE ION

Source
  • homo sapiens (human)
  • unidentified (others)
  • synthetic construct (others)
Keywordshydrolase/rna / RNA-binding protein / microRNA / target directed microRNA decay / HYDROLASE / hydrolase-rna complex / rna binding protein/rna / RNA BINDING PROTEIN / rna binding protein-rna complex

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