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Structure paper

TitleThe crystal structure of the protein kinase HIPK2 reveals a unique architecture of its CMGC-insert region.
Journal, issue, pagesJ. Biol. Chem., Vol. 294, Page 13545-13559, Year 2019
Publish dateMay 30, 2019 (structure data deposition date)
AuthorsAgnew, C. / Liu, L. / Liu, S. / Xu, W. / You, L. / Yeung, W. / Kannan, N. / Jablons, D. / Jura, N.
External linksJ. Biol. Chem. / PubMed:31341017
MethodsX-ray diffraction
Resolution2.194 Å
Structure data

PDB-6p5s:
HIPK2 kinase domain bound to CX-4945
Method: X-RAY DIFFRACTION / Resolution: 2.194 Å

Chemicals

ChemComp-3NG:
5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid / chemotherapy, inhibitor*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
Keywordstransferase/transferase inhibitor / Homeodomain Interacting Protein / Kinase / p53 regulator / Mitophagy / Fibrosis / NUCLEAR PROTEIN / transferase-transferase inhibitor complex

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