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TitleMachilin A Inhibits Tumor Growth and Macrophage M2 Polarization Through the Reduction of Lactic Acid.
Journal, issue, pagesCancers (Basel), Vol. 11, Year 2019
Publish dateMar 20, 2018 (structure data deposition date)
AuthorsChung, T.-W. / Kim, E.-Y. / Han, C.W. / Park, S.Y. / Jeong, M.S. / Yoon, D. / Choi, H.-J. / Jin, L. / Park, M.-J. / Kwon, Y.J. ...Chung, T.-W. / Kim, E.-Y. / Han, C.W. / Park, S.Y. / Jeong, M.S. / Yoon, D. / Choi, H.-J. / Jin, L. / Park, M.-J. / Kwon, Y.J. / Lee, H. / Kim, K.-J. / Park, K.H. / Kim, S. / Jang, S.B. / Ha, K.-T.
External linksCancers (Basel) / PubMed:31324019
MethodsX-ray diffraction
Resolution2.394 - 2.929 Å
Structure data

PDB-5zjd:
Lactate dehydrogenase with NADH and MLA
Method: X-RAY DIFFRACTION / Resolution: 2.394 Å

PDB-5zje:
LDHA-mla
Method: X-RAY DIFFRACTION / Resolution: 2.929 Å

PDB-5zjf:
LDHA-MA
Method: X-RAY DIFFRACTION / Resolution: 2.602 Å

Chemicals

ChemComp-NAI:
1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE

ChemComp-MLI:
MALONATE ION

ChemComp-HOH:
WATER

ChemComp-9G9:
5,5'-[(2R,3S)-2,3-dimethylbutane-1,4-diyl]bis(2H-1,3-benzodioxole)

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / LDHA / NADH / LDHA wt / malonate / inhibitor / machilin a

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