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Structure paper

TitleMolecular basis of egg coat cross-linking sheds light on ZP1-associated female infertility.
Journal, issue, pagesNat Commun, Vol. 10, Page 3086-3086, Year 2019
Publish dateApr 29, 2018 (structure data deposition date)
AuthorsNishimura, K. / Dioguardi, E. / Nishio, S. / Villa, A. / Han, L. / Matsuda, T. / Jovine, L.
External linksNat Commun / PubMed:31300655
MethodsX-ray diffraction
Resolution2.3 - 3.1 Å
Structure data

PDB-6gf6:
Molecular basis of egg coat filament cross-linking: high-resolution structure of the partially deglycosylated ZP1 ZP-N1 domain homodimer
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-6gf7:
Molecular basis of egg coat filament cross-linking: Zn-SAD structure of the partially deglycosylated ZP1 ZP-N1 domain homodimer
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-6gf8:
Molecular basis of egg coat filament cross-linking: structure of the glycosylated ZP1 ZP-N1 domain homodimer
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-ZN:
Unknown entry

ChemComp-MPD:
(4S)-2-METHYL-2,4-PENTANEDIOL / precipitant*YM

Source
  • gallus gallus (chicken)
KeywordsCELL ADHESION / Zona pellucida / ZP1 / ZP-N domain / ZP module / ZP domain / egg coat filament cross-linking / egg coat penetration by sperm

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