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Structure paper

TitleStructure-based design of a hyperthermostable AgUricase for hyperuricemia and gout therapy.
Journal, issue, pagesActa Pharmacol. Sin., Vol. 40, Page 1364-1372, Year 2019
Publish dateMar 27, 2019 (structure data deposition date)
AuthorsShi, Y. / Wang, T. / Zhou, X.E. / Liu, Q.F. / Jiang, Y. / Xu, H.E.
External linksActa Pharmacol. Sin. / PubMed:31253939
MethodsX-ray diffraction
Resolution1.99 Å
Structure data

PDB-6oe8:
The crystal structure of hyper-thermostable AgUricase mutant K12C/E286C
Method: X-RAY DIFFRACTION / Resolution: 1.99 Å

Chemicals

ChemComp-PG4:
TETRAETHYLENE GLYCOL / precipitant*YM

ChemComp-PGE:
TRIETHYLENE GLYCOL

ChemComp-MLI:
MALONATE ION

ChemComp-HOH:
WATER

Source
  • arthrobacter globiformis (bacteria)
KeywordsOXIDOREDUCTASE / Uricase / Arthrobacter globiformis / thermostability / disulfide cross-linking

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