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IF

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Structure paper

TitleSTING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition.
Journal, issue, pagesCell, Vol. 178, Page 290-301.e10, Year 2019
Publish dateFeb 14, 2018 (structure data deposition date)
AuthorsErgun, S.L. / Fernandez, D. / Weiss, T.M. / Li, L.
External linksCell / PubMed:31230712
MethodsX-ray diffraction
Resolution1.95 - 2.396 Å
Structure data

PDB-6cff:
Stimulator of Interferon Genes Human
Method: X-RAY DIFFRACTION / Resolution: 2.396 Å

PDB-6cy7:
Human Stimulator of Interferon Genes
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-6dnk:
Human Stimulator of Interferon Genes
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

Chemicals

ChemComp-2BA:
(2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8

ChemComp-HOH:
WATER

ChemComp-IMD:
IMIDAZOLE

ChemComp-GOL:
GLYCEROL

ChemComp-1SY:
cGAMP

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / human STING / complex / cyclic-di-AMP / TMEM173 / wild type / 230G/232R / Ala230 allelle / 230A/232R / 2' / 3'-cGAMP

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