EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Molecular determinants of the mechanism and substrate specificity ofClostridium difficileproline-proline endopeptidase-1.
ジャーナル・号・ページ	J. Biol. Chem., Vol. 294, Page 11525-11535, Year 2019
掲載日	2019年3月24日 (構造データの登録日)
著者	Pichlo, C. / Juetten, L. / Wojtalla, F. / Schacherl, M. / Diaz, D. / Baumann, U.
リンク	J. Biol. Chem. / PubMed:31182482
手法	X線回折 / NMR (溶液)
解像度	1.052 - 2.06 Å
構造データ	PDB-6r4w: Crystal structure of apo PPEP-1(E143A/Y178F) in complex with substrate peptide Ac-EVNAPVP-CONH2 手法: X-RAY DIFFRACTION / 解像度: 1.391 Å PDB-6r4x: Crystal structure of PPEP-1(E143A/Y178F) in complex with substrate peptide Ac-EVNPAVP-CONH2 手法: X-RAY DIFFRACTION / 解像度: 1.831 Å PDB-6r4y: Crystal structure of holo PPEP-1(E143A/Y178F) in complex with product peptide Ac-EVNP-CO2 (substrate peptide: Ac-EVNPAVP-CONH2) 手法: X-RAY DIFFRACTION / 解像度: 1.452 Å PDB-6r4z: Crystal structure of holo PPEP-1(E143A/Y178F) in complex with product peptide Ac-EVNP-CO2 (substrate peptide: Ac-EVNPPVP-CONH2) 手法: X-RAY DIFFRACTION / 解像度: 1.052 Å PDB-6r50: Crystal structure of holo PPEP-1(E143A/Y178F) in complex with substrate peptide Ac-EVNAPVP-CONH2 手法: X-RAY DIFFRACTION / 解像度: 1.807 Å PDB-6r51: Crystal structure of apo PPEP-1(E143A/Y178F) in complex with fibrinogen-derived substrate peptide Ac-SLRPAPP-CONH2 手法: X-RAY DIFFRACTION / 解像度: 1.94 Å PDB-6r52: Crystal structure of PPEP-1(K101A) 手法: X-RAY DIFFRACTION / 解像度: 2.022 Å PDB-6r53: Crystal structure of PPEP-1(K101R) 手法: X-RAY DIFFRACTION / 解像度: 1.798 Å PDB-6r54: Crystal structure of PPEP-1(E184A) 手法: X-RAY DIFFRACTION / 解像度: 1.417 Å PDB-6r55: Crystal structure of PPEP-1(E184K) 手法: X-RAY DIFFRACTION / 解像度: 1.401 Å PDB-6r56: Crystal structure of PPEP-1(K101E/E184K) 手法: X-RAY DIFFRACTION / 解像度: 1.77 Å PDB-6r57: Crystal structure of PPEP-1(E143A/Y178F/E184A) in complex with substrate peptide Ac-EVNPPVP-CONH2 手法: X-RAY DIFFRACTION / 解像度: 1.899 Å PDB-6r58: Crystal structure of PPEP-1(E143A/Y178F/E184A) in complex with substrate peptide Ac-EVNAPVP-CONH2 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-6r59: Crystal structure of PPEP-1(E143A/Y178F) in complex with substrate peptide Ac-EVAPPVP-NH2 手法: X-RAY DIFFRACTION / 解像度: 1.65 Å PDB-6r5a: Crystal structure of PPEP-1(W103F) 手法: X-RAY DIFFRACTION / 解像度: 1.48 Å PDB-6r5b: Crystal structure of PPEP-1(W103H/E143A/Y178F) in complex with substrate peptide Ac-EVNPPVP-CONH2 手法: X-RAY DIFFRACTION / 解像度: 2.06 Å PDB-6r5c: Crystal structure of PPEP-1(W103F/E143A/Y178F) in complex with substrate peptide Ac-EVNPPVP-CONH2 手法: X-RAY DIFFRACTION / 解像度: 1.881 Å PDB-6r9z: 3D NMR solution structure of ligand peptide (Ac)EVNPPVP of Pro-Pro endopeptidase-1 手法: SOLUTION NMR
化合物	ChemComp-ZN: Unknown entry ChemComp-HOH: WATER ChemComp-NI: NICKEL (II) ION ChemComp-PO4: PHOSPHATE ION / ホスファ-ト ChemComp-TRS: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / トリス(ヒドロキシメチル)メチルアンモニウム / pH緩衝剤*YM
由来	peptoclostridium difficile (バクテリア) clostridioides difficile (バクテリア) homo sapiens (ヒト)
キーワード	HYDROLASE / Pro-Pro endopeptidase 1 / zinc metallopeptidase / Clostridium difficile / virulence factor / synthetic model peptide / Pro-Pro endopeptidase-1