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TitleBlocking Antibodies Targeting the CD39/CD73 Immunosuppressive Pathway Unleash Immune Responses in Combination Cancer Therapies.
Journal, issue, pagesCell Rep, Vol. 27, Page 2411-2425.e9, Year 2019
Publish dateOct 18, 2018 (structure data deposition date)
AuthorsPerrot, I. / Michaud, H.A. / Giraudon-Paoli, M. / Augier, S. / Docquier, A. / Gros, L. / Courtois, R. / Dejou, C. / Jecko, D. / Becquart, O. ...Perrot, I. / Michaud, H.A. / Giraudon-Paoli, M. / Augier, S. / Docquier, A. / Gros, L. / Courtois, R. / Dejou, C. / Jecko, D. / Becquart, O. / Rispaud-Blanc, H. / Gauthier, L. / Rossi, B. / Chanteux, S. / Gourdin, N. / Amigues, B. / Roussel, A. / Bensussan, A. / Eliaou, J.F. / Bastid, J. / Romagne, F. / Morel, Y. / Narni-Mancinelli, E. / Vivier, E. / Paturel, C. / Bonnefoy, N.
External linksCell Rep / PubMed:31116985
MethodsX-ray diffraction
Resolution2.78 Å
Structure data

PDB-6hxw:
structure of human CD73 in complex with antibody IPH53
Method: X-RAY DIFFRACTION / Resolution: 2.78 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsIMMUNE SYSTEM / Inhibitor antibody

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