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Structure paper

TitleDNA specificities modulate the binding of human transcription factor A to mitochondrial DNA control region.
Journal, issue, pagesNucleic Acids Res., Vol. 47, Page 6519-6537, Year 2019
Publish dateAug 9, 2018 (structure data deposition date)
AuthorsCuppari, A. / Fernandez-Millan, P. / Battistini, F. / Tarres-Sole, A. / Lyonnais, S. / Iruela, G. / Ruiz-Lopez, E. / Enciso, Y. / Rubio-Cosials, A. / Prohens, R. ...Cuppari, A. / Fernandez-Millan, P. / Battistini, F. / Tarres-Sole, A. / Lyonnais, S. / Iruela, G. / Ruiz-Lopez, E. / Enciso, Y. / Rubio-Cosials, A. / Prohens, R. / Pons, M. / Alfonso, C. / Toth, K. / Rivas, G. / Orozco, M. / Sola, M.
External linksNucleic Acids Res. / PubMed:31114891
MethodsX-ray diffraction
Resolution3.05 - 3.1 Å
Structure data

PDB-6hb4:
TFAM in Complex with Site-Y
Method: X-RAY DIFFRACTION / Resolution: 3.05 Å

PDB-6hc3:
TFAM bound to Site-X
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-1PE:
PENTAETHYLENE GLYCOL / precipitant*YM

ChemComp-TLA:
L(+)-TARTARIC ACID

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsDNA BINDING PROTEIN / HMG-box / Transcription activator / Mitochondrial DNA / mtDNA Control region / DNA Compaction / Transcription factor / mitochondria

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