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Structure paper

TitleThe Tumor Suppressor ING5 Is a Dimeric, Bivalent Recognition Molecule of the Histone H3K4me3 Mark.
Journal, issue, pagesJ. Mol. Biol., Vol. 431, Page 2298-2319, Year 2019
Publish dateNov 14, 2016 (structure data deposition date)
AuthorsOrmaza, G. / Rodriguez, J.A. / Ibanez de Opakua, A. / Merino, N. / Villate, M. / Gorrono, I. / Rabano, M. / Palmero, I. / Vilaseca, M. / Kypta, R. ...Ormaza, G. / Rodriguez, J.A. / Ibanez de Opakua, A. / Merino, N. / Villate, M. / Gorrono, I. / Rabano, M. / Palmero, I. / Vilaseca, M. / Kypta, R. / Vivanco, M.D.M. / Rojas, A.L. / Blanco, F.J.
External linksJ. Mol. Biol. / PubMed:31026448
MethodsX-ray diffraction
Resolution3.1 - 3.2 Å
Structure data

PDB-5me8:
N-terminal domain of the human tumor suppressor ING5
Method: X-RAY DIFFRACTION / Resolution: 3.2 Å

PDB-5mto:
N-terminal domain of the human tumor suppressor ING5 C19S mutant
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

Chemicals

ChemComp-MPD:
(4S)-2-METHYL-2,4-PENTANEDIOL / precipitant*YM

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

ChemComp-NA:
Unknown entry

ChemComp-SO4:
SULFATE ION

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / tumor suppressor / ING5 / asymmetric dimer / SIGNALING PROTEIN

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