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TitleA CD40L-targeting protein reduces autoantibodies and improves disease activity in patients with autoimmunity.
Journal, issue, pagesSci Transl Med, Vol. 11, Year 2019
Publish dateNov 30, 2017 (structure data deposition date)
AuthorsKarnell, J.L. / Albulescu, M. / Drabic, S. / Wang, L. / Moate, R. / Baca, M. / Oganesyan, V. / Gunsior, M. / Thisted, T. / Yan, L. ...Karnell, J.L. / Albulescu, M. / Drabic, S. / Wang, L. / Moate, R. / Baca, M. / Oganesyan, V. / Gunsior, M. / Thisted, T. / Yan, L. / Li, J. / Xiong, X. / Eck, S.C. / de Los Reyes, M. / Yusuf, I. / Streicher, K. / Muller-Ladner, U. / Howe, D. / Ettinger, R. / Herbst, R. / Drappa, J.
External linksSci Transl Med / PubMed:31019027
MethodsX-ray diffraction
Resolution2.82 Å
Structure data

PDB-6brb:
Novel non-antibody protein scaffold targeting CD40L
Method: X-RAY DIFFRACTION / Resolution: 2.82 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • escherichia coli (E. coli)
KeywordsSTRUCTURAL PROTEIN/IMMUNE SYSTEM / Tn3 related / TNF ligand related / STRUCTURAL PROTEIN-IMMUNE SYSTEM complex

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