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Title | Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders. |
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Journal, issue, pages | J. Med. Chem., Vol. 62, Page 4884-4901, Year 2019 |
Publish date | Jan 3, 2019 (structure data deposition date) |
Authors | Gurney, M.E. / Nugent, R.A. / Mo, X. / Sindac, J.A. / Hagen, T.J. / Fox III, D. / O'Donnell, J.M. / Zhang, C. / Xu, Y. / Zhang, H.T. ...Gurney, M.E. / Nugent, R.A. / Mo, X. / Sindac, J.A. / Hagen, T.J. / Fox III, D. / O'Donnell, J.M. / Zhang, C. / Xu, Y. / Zhang, H.T. / Groppi, V.E. / Bailie, M. / White, R.E. / Romero, D.L. / Vellekoop, A.S. / Walker, J.R. / Surman, M.D. / Zhu, L. / Campbell, R.F. |
External links | J. Med. Chem. / PubMed:31013090 |
Methods | X-ray diffraction |
Resolution | 2.15 - 2.45 Å |
Structure data | PDB-6njh: PDB-6nji: PDB-6njj: |
Chemicals | ChemComp-ZN: ChemComp-MG: ChemComp-KRD: ChemComp-HOH: ChemComp-KR4: ChemComp-KR7: ChemComp-BTB: ChemComp-SO4: ChemComp-EDO: |
Source |
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Keywords | HYDROLASE/HYDROLASE INHIBITOR / PDE4D / CAMP-SPECIFIC 3'5'-CYCLIC PHOSPHODIESTERASE 4D / UCR2 / cAMP / HYDROLASE / HYDROLASE-HYDROLASE INHIBITOR complex |