+Search query
-Structure paper
Title | Packaging of DNA origami in viral capsids. |
---|---|
Journal, issue, pages | Nanoscale, Vol. 11, Issue 21, Page 10160-10166, Year 2019 |
Publish date | May 30, 2019 |
Authors | Idit Kopatz / Ran Zalk / Yael Levi-Kalisman / Efrat Zlotkin-Rivkin / Gabriel A Frank / Stanislav Kler / |
PubMed Abstract | Here we show the encapsulation of 35 nm diameter, nearly-spherical, DNA origami by self-assembly of SV40-like (simian virus 40) particles. The self-assembly of this new type of nanoparticles is ...Here we show the encapsulation of 35 nm diameter, nearly-spherical, DNA origami by self-assembly of SV40-like (simian virus 40) particles. The self-assembly of this new type of nanoparticles is highly reproducible and efficient. The structure of these particles was determined by cryo-EM. The capsid forms a regular SV40 lattice of T = 7d icosahedral symmetry and the structural features of encapsulated DNA origami are fully visible. These particles are a promising biomaterial for use in various medical applications. |
External links | Nanoscale / PubMed:30994643 |
Methods | EM (single particle) |
Resolution | 6.8 - 21.0 Å |
Structure data | EMDB-4648: EMDB-4651: EMDB-4652: EMDB-4653: |