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TitleSmall-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia.
Journal, issue, pagesCancer Cell, Vol. 35, Page 677-691.e10, Year 2019
Publish dateSep 4, 2018 (structure data deposition date)
AuthorsHuang, Y. / Su, R. / Sheng, Y. / Dong, L. / Dong, Z. / Xu, H. / Ni, T. / Zhang, Z.S. / Zhang, T. / Li, C. ...Huang, Y. / Su, R. / Sheng, Y. / Dong, L. / Dong, Z. / Xu, H. / Ni, T. / Zhang, Z.S. / Zhang, T. / Li, C. / Han, L. / Zhu, Z. / Lian, F. / Wei, J. / Deng, Q. / Wang, Y. / Wunderlich, M. / Gao, Z. / Pan, G. / Zhong, D. / Zhou, H. / Zhang, N. / Gan, J. / Jiang, H. / Mulloy, J.C. / Qian, Z. / Chen, J. / Yang, C.G.
External linksCancer Cell / PubMed:30991027
MethodsX-ray diffraction
Resolution2.2 Å
Structure data

PDB-6akw:
Crystal structure of RNA dioxygenase bound with an inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-AKG:
2-OXOGLUTARIC ACID

ChemComp-8S3:
2-[[2,6-bis(chloranyl)-4-(3,5-dimethyl-1,2-oxazol-4-yl)phenyl]amino]benzoic acid

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / RNA demethylase / inhibitor / oxidation / RNA BINDING PROTEIN

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