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TitleBiosynthesis of l-4-Chlorokynurenine, an Antidepressant Prodrug and a Non-Proteinogenic Amino Acid Found in Lipopeptide Antibiotics.
Journal, issue, pagesAngew. Chem. Int. Ed. Engl., Vol. 58, Page 8394-8399, Year 2019
Publish dateJan 24, 2019 (structure data deposition date)
AuthorsLuhavaya, H. / Sigrist, R. / Chekan, J.R. / McKinnie, S.M.K. / Moore, B.S.
External linksAngew. Chem. Int. Ed. Engl. / PubMed:30963655
MethodsX-ray diffraction
Resolution1.74 Å
Structure data

PDB-6nsd:
Tar14, tryptophan C-6 flavin-dependent halogenase (chlorinase) from taromycin biosynthesis
Method: X-RAY DIFFRACTION / Resolution: 1.74 Å

Chemicals

ChemComp-FAD:
FLAVIN-ADENINE DINUCLEOTIDE / FAD*YM

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • saccharomonospora sp. cnq490 (bacteria)
KeywordsBIOSYNTHETIC PROTEIN / halogenase / flavin / tryptophan / taromycin

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