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Structure paper

TitleSuccessive crystal structure snapshots suggest the basis for MHC class I peptide loading and editing by tapasin.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 116, Page 5055-5060, Year 2019
Publish dateApr 13, 2018 (structure data deposition date)
AuthorsHafstrand, I. / Sayitoglu, E.C. / Apavaloaei, A. / Josey, B.J. / Sun, R. / Han, X. / Pellegrino, S. / Ozkazanc, D. / Potens, R. / Janssen, L. ...Hafstrand, I. / Sayitoglu, E.C. / Apavaloaei, A. / Josey, B.J. / Sun, R. / Han, X. / Pellegrino, S. / Ozkazanc, D. / Potens, R. / Janssen, L. / Nilvebrant, J. / Nygren, P.A. / Sandalova, T. / Springer, S. / Georgoudaki, A.M. / Duru, A.D. / Achour, A.
External linksProc. Natl. Acad. Sci. USA / PubMed:30808808
MethodsX-ray diffraction
Resolution1.78 - 2.3 Å
Structure data

PDB-6gb5:
Structure of H-2Db with truncated SEV peptide and GL
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-6gb6:
Structure of H-2Kb with dipeptide GL
Method: X-RAY DIFFRACTION / Resolution: 1.78 Å

PDB-6gb7:
Structure of H-2Db with scoop loop from tapasin
Method: X-RAY DIFFRACTION / Resolution: 2.15 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-GLY:
GLYCINE

ChemComp-LEU:
LEUCINE

Source
  • mus musculus (house mouse)
  • sendai virus
KeywordsIMMUNE SYSTEM / MHC / MHC-I / H-2Kb / H-2K(b) tapasin / H-2K(b)

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