Database of articles cited by EMDB/PDB/SASBDB data

Keywords
Structure methods	All X-ray diffraction NMR electron microscopy small angle scattering neutron diffraction fiber diffraction powder diffraction infrared spectroscopy EPR fluorescence transfer theoretical model Hybrid
Author
Journal
IF	>30 >20 >10 >5 all

Title	Binding to an Unusual Inactive Kinase Conformation by Highly Selective Inhibitors of Inositol-Requiring Enzyme 1 alpha Kinase-Endoribonuclease.
Journal, issue, pages	J. Med. Chem., Vol. 62, Page 2447-2465, Year 2019
Publish date	Oct 9, 2018 (structure data deposition date)
Authors	Colombano, G. / Caldwell, J.J. / Matthews, T.P. / Bhatia, C. / Joshi, A. / McHardy, T. / Mok, N.Y. / Newbatt, Y. / Pickard, L. / Strover, J. ...Colombano, G. / Caldwell, J.J. / Matthews, T.P. / Bhatia, C. / Joshi, A. / McHardy, T. / Mok, N.Y. / Newbatt, Y. / Pickard, L. / Strover, J. / Hedayat, S. / Walton, M.I. / Myers, S.M. / Jones, A.M. / Saville, H. / McAndrew, C. / Burke, R. / Eccles, S.A. / Davies, F.E. / Bayliss, R. / Collins, I.
External links	J. Med. Chem. / PubMed:30779566
Methods	X-ray diffraction
Resolution	2.14 - 2.73 Å
Structure data	PDB-6hv0: IRE1 kinase/RNase in complex with imidazo[1,2-b]pyridazin-8-amine compound 33 Method: X-RAY DIFFRACTION / Resolution: 2.73 Å PDB-6hx1: IRE1 ALPHA IN COMPLEX WITH imidazo[1,2-b]pyridazin-8-amine compound 2 Method: X-RAY DIFFRACTION / Resolution: 2.14 Å
Chemicals	ChemComp-GUK: 6-chloranyl-3-(2~{H}-indazol-5-yl)-~{N}-propan-2-yl-imidazo[1,2-b]pyridazin-8-amine ChemComp-HOH: WATER ChemComp-GXK: 6-chloranyl-~{N}-(cyclopropylmethyl)-3-(2~{H}-indazol-5-yl)imidazo[1,2-b]pyridazin-8-amine
Source	homo sapiens (human)
Keywords	SIGNALING PROTEIN / Unfolded Protein Response Allosteric inhibitor / TRANSFERASE / IRE1 KINASE / PROTEROS BIOSTRUCTURES GMBH