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Structure paper

TitleEngineered botulinum neurotoxin B with improved binding to human receptors has enhanced efficacy in preclinical models.
Journal, issue, pagesSci Adv, Vol. 5, Page eaau7196-eaau7196, Year 2019
Publish dateMar 29, 2018 (structure data deposition date)
AuthorsElliott, M. / Favre-Guilmard, C. / Liu, S.M. / Maignel, J. / Masuyer, G. / Beard, M. / Boone, C. / Carre, D. / Kalinichev, M. / Lezmi, S. ...Elliott, M. / Favre-Guilmard, C. / Liu, S.M. / Maignel, J. / Masuyer, G. / Beard, M. / Boone, C. / Carre, D. / Kalinichev, M. / Lezmi, S. / Mir, I. / Nicoleau, C. / Palan, S. / Perier, C. / Raban, E. / Zhang, S. / Dong, M. / Stenmark, P. / Krupp, J.
External linksSci Adv / PubMed:30746458
MethodsX-ray diffraction
Resolution2 - 2.5 Å
Structure data

PDB-6g5f:
Crystal structure of an engineered Botulinum Neurotoxin type B mutant E1191M/S1199Y in complex with human synaptotagmin 1
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-6g5g:
Crystal structure of an engineered Botulinum Neurotoxin type B mutant E1191M/S1199Y in complex with human synaptotagmin 2
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-6g5k:
Crystal structure of the binding domain of Botulinum Neurotoxin type B in complex with human synaptotagmin 1
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-MLI:
MALONATE ION

ChemComp-HOH:
WATER

ChemComp-MG:
Unknown entry

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-TRS:
2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

ChemComp-ACT:
ACETATE ION

Source
  • clostridium botulinum (bacteria)
  • homo sapiens (human)
KeywordsTOXIN / botulinum toxin / neurotoxin / protein engineering / receptor binding

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